Research Fellow in Biophysics of Amyloid Formation

Research Fellow in Biophysics of Amyloid Formation
Astbury Centre for Structural Molecular Biology
School of Molecular and Cellular Biology

Are you an ambitious researcher looking for your next challenge? Do you have an established background in biophysical analysis of amyloid formation mechanisms and want to help to develop new routes to combat amyloid diseases? Do you want to further your career in one of the UKs leading research intensive Universities?

We are looking for an outstanding postdoctoral research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, using α-synuclein as a model system. This role will use NMR spectroscopy, combined with other biochemical, biophysical and computational methods, to understand how the properties of the initially disordered α-synuclein monomer funnels its self-assembly into different polymorphic amyloid structures. In parallel, you will use C. elegans as a model organism to follow aggregate formation of α-synuclein and its natural variants in a living organism.

You will be based in the laboratory of Professor Sheena Radford and work closely with our collaborators and other members of the amyloid team (funded by Wellcome, BBSRC and the Royal Society). You should have a PhD (or be close to completing one) in Structural Biology, Biophysics, Biochemistry, or a related discipline, and you should have extensive experience of using biophysical and computational methods to elucidate biological mechanisms. Experience of working in the amyloid field is required.

What we offer in return

• 26 days holiday plus approx.16 Bank Holidays/days that the University is closed by custom (including Christmas) – That’s 42 days a year!

• Generous pension scheme plus life assurance– the University contributes 14.5% of salary

• Health and Wellbeing: Discounted staff membership options at The Edge, our state-of-the-art Campus gym, with a pool, sauna, climbing wall, cycle circuit, and sports halls.

• Personal Development: Access to courses run by our Organisational Development & Professional Learning team.

• Access to on-site childcare, shopping discounts and travel schemes are also available.

And much more!

To explore the post further or for any queries you may have, please contact:

Professor Sheena Radford, Astbury Professor of Biophysics

Tel: +44 (0)113 343 3170

Email: [email protected]

Closing Date: 03 Dec 2024

Section: Research

Salary: £39,105 to £46,485 per annum