Senior Research Associate in Trypanosome Differentiation

Overview of the Project

Lancaster University’s Division of Biomedical and Life Sciences seeks to appoint a Post-Doctoral Research Associate to join the laboratory of Dr Federico Rojas for a period of five years on a BBSRC-funded project. This full-time role will ideally begin in April 2025.

This research will investigate how the NEDD8 pathway regulates differentiation in Trypanosoma brucei, specifically the transition from replicative slender forms to cell cycle-arrested (G0/G1) stumpy forms, using genetic and proteomic techniques. Identifying novel components of the neddylation machinery will provide valuable insights into trypanosome biology and has the potential to uncover therapeutic targets. Given the distinct evolutionary position of these parasites, our findings will also contribute to understanding ubiquitin-like modification (UBL) regulation across eukaryotic life.

Role Responsibilities

As part of a dedicated team within our Division, you will be responsible for:

• Collecting and analysing data from genetic and proteomic assays

Coordinating experiments focused on the neddylation machinery in T. brucei

Designing and implementing experimental protocols using cell culture and molecular biology techniques

Mapping and classifying regulatory mechanisms in the differentiation process

Writing up research findings for publication and conference presentations

Assisting in disseminating project outcomes to key stakeholders

Maintaining ethical and quality standards throughout the study

About You

We are interested in hearing from candidates who have:

• A PhD in Biochemistry, Cell Biology, or a related field

Experience, ideally with but not exclusively, trypanosome cell biology, quantitative proteomics, or molecular biology

Competency in cell culture techniques and data analysis and interpretation

Hands-on experience in handling mice and conducting infection studies in murine models.

Strong organisational skills and attention to detail

Enthusiasm to work collaboratively within a multi-disciplinary team

Why Work with Us

This role is based within the Division of Biomedical and Life Sciences, part of Lancaster University’s Faculty of Health and Medicine. Known for its research excellence, the Division is equipped with Biohazard Category 2 and 3 laboratories, supporting innovative research in health and disease.

Lancaster University is a research-intensive institution, with 99% of its research environment rated as world-leading or internationally excellent in REF 2021. The main Lancaster Bailrigg campus offers numerous on-site amenities, including cafés, a sports centre, multi faith prayer and quiet spaces and scenic green trails and parkland.

We offer a competitive benefits package, including:

• Competitive salary with annual reviews

Generous employer pension scheme

39 days of annual leave (inclusive of university closure days)

Family-friendly policies supporting work-life balance

Flexible benefits tailored to individual needs

As part of our research team, you will also benefit from:

• A bespoke induction and researcher development programme

Organisational development programmes to expand your research and teaching skills

Ten researcher development days under the Researcher Development Concordat

For an informal discussion about the role, please contact Dr Federico Rojas at [email protected]

Discover more about working at Lancaster University and our benefits at https://www.lancaster.ac.uk/jobs

Closing Date: 02 Feb 2025

Department: Research

Salary: £39,105 to £45,163 (Full time, indefinite with end date)